![]() Phosphorylation of the lamins is catalyzed by the Cdc2 protein kinase, which was introduced in Chapter 7 (see Figure 7.40) and will be discussed in detail in Chapter 14 as a central regulator of mitosis. Disassembly of the nuclear lamina results from phosphorylation of the lamins, which causes the filaments to break down into individual lamin dimers ( Figure 8.31). ![]() The nuclear lamina is composed of fibrous proteins, lamins, which associate with each other to form filaments. The best understood of these events is depolymerization of the nuclear lamina-the meshwork of filaments underlying the nuclear membrane. In open mitosis, the nuclear envelope breaks down and then re-forms around the two sets of separated (more.)ĭisassembly of the nuclear envelope, which parallels a similar breakdown of the endoplasmic reticulum, involves changes in all three of its components: The nuclear membranes are fragmented into vesicles, the nuclear pore complexes dissociate, and the nuclear lamina depolymerizes. ![]() ![]() In closed mitosis, the nuclear envelope remains intact and chromosomes migrate to opposite poles of a spindle within the nucleus. ![]()
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